Checking whether i can rmb anot Cell Mediated :(
Cell Mediated.
Part 1
1. Viral infection
2. Macrophage engulf,ingest the pathogen (not completely).
3. Some fragment of the foreign antigen bought up to macrophage surface and combine to the MHC 2-protein which is located at the cell surface.
4. Macrophage become the APC (Antigen presenting cell) Whole thing call antigen MHC 2 complex
Part 2
1. Helper T cell will cognated with the Complex with aids of coreceptor CD4+
2. The complex and Helper T will be hold together by CD4.
3. This activates the complex (APC)and stimulates the secretion of IL 1 (cytokines)
4. IL 1 will activates the Helpher T to divide and increase in size,and Helper T will produce IL 2.
5. IL 2 in turns stimulates more production of Helper T cells and even more interleukins produced by Helper T.
IL 2 also stimulates the NK cells and B-cells.
IL 2 also stimulates the poliferation of Cytotoxic T cells
IL 2 also stimulates Cytotoxic T to release perforin
Part 3
1. Cytotoxic T cells have coreceptor CD8+ will recognize the viral antigen on MHC 1-protein.
2. Perforin is released. by Cytotoxic T.
3. Perforin cre8 holes,pores on target cell's membrane. causes lysis to happen,burst or shrink whatever and destroyed
4. Antibodies circulating the virus will destroy the viral cell
Humoral response
Part 1
1. Viral infection
2. Macrophage engulf,ingest the pathogen (not completely).
3. Some fragment of the foreign antigen bought up to macrophage surface and combine to the MHC 2-protein which is located at the cell surface.
4. Macrophage become the APC (Antigen presenting cell) Whole thing call antigen MHC 2 complex
Part 2
1. Helper T cell will cognated with the Complex with aids of coreceptor CD4+
2. The complex and Helper T will be hold together by CD4.
3. Helper T start to divide and activated
Part 3
1. B-cells with MHC 2 on their surface will displace T-dependent antigen.
2. B-cell become APC
3. Activated helper T on step 3 part 2 will recognize the antigen being displaced bcz same antigen source.
4. the binding will stimualates the release of IL 2.
5. IL 2 will stimulate B-cell to poliferate.
6. Plasma B-cells produce numerous clones antibodies. and to the bloodstream and body fluid and to the infection site.
7. Memory B-cells for future use,if and only if exposed to same pathogen attack
End.